ABSTRACT
Background: An increase of oxidative species in our body is implicated in the expansion and progression of chronic diseases. Identification of new natural antioxidants resources may provide hopeful expectancies for the upgrading of human healthcare concerning the prevention of the expansion of the chronic diseases. Objective: The objective of this study was to perform the isolation, chemical analysis, and antioxidative activity of the volatile oils of Moringa peregrina and Moringa oleifera from Saudi Arabia. Method: The volatile oils were isolated by hydrodistillation method. The physicochemical characteristics were also analyzed by the reported methods. The DPPH method was used to assess the antioxidant potential of the isolated oils. Result: The hydrodistillation method provided the volatile oil from M. peregrina and M. oleifera in 0.06% and 0.05% yield, respectively. The color, odour, solubility in water, ethanol, methanol, n-hexane, dichloromethane, ethyl acetate, chloroform, and petroleum ether, refractive index, and the acid value of these isolated oils were similar. The isolated volatile oils from M. peregrina and M. oleifera provided good IC50 values, which were 85.48% and 85.57%, respectively, with respect to ascorbic acid (100%). Conclusion: It is expected that the chemical composition of the volatile oils of these two species of Moringa might be similar, which can be identified by their GC-MS analysis. Accordingly, further investigations are suggested.
ABSTRACT
Diabetes mellitus is a metabolic disorder, that affects almost all the cells of the body. Well documented complications of DMinclude, neuropathy, nephropathy, microangiopathy, and retinopathy. The negative impact of the disorder is also found inother cells, including male reproductive system. In this study, fifty adult Wistar albino male rats were used. The rats weredivided into 10 groups, each group comprised of 5 rats. Diabetes was induced by intraperitoneal injection of STZ, effects ofDM were observed on the sperm producing cells then preventive as well as curative effects of Metformin, Punica granatum,Nigella sativa and Zingiber officinale were observed. It was found that all the substances prevent as well as repair/cure thedamage caused by DM to the seminiferous tubules and other structures. The results of this study show that Metforminthough prevented and caused repair to the damaged cells as well, but was not as effective as Punica granatum, Nigellasativa and Zingiber officinale.